Effect and Side Effects of Dianabol – Metandienone

Effect of Dianabol

Dianabol (Methandrostenolone) – historical and general information about the drug
Dianabol has some limitations when it comes to C17 Alpha Alkylation. As already mentioned, the methylation process activates the drug when taken orally, and also ensures its bioavailability; Due to this change, the anabolic steroid is not broken down in the liver.

However, the disadvantage of the modification is the increased hepatotoxicity of the drug. Alkylation of C17-alpha increases the resistance of the anabolic steroid to hepatic degradation and any compound with additional resistance to hepatic metabolism is more hepatotoxic.

Therefore, for many users, the duration of the course should be 4-6 weeks. This maintains normal liver function and ensures the recovery of the organ at the end of the cycle. As a result of the use of Dianabol, an increase in liver enzymes is often observed, followed by a return to normal after stopping the drug. Due to the risk of hepatotoxic effects, methandrostenolone is mainly used as an adjunct.

Neither this drug nor any other oral anabolic steroid should ever be used as monotherapy. It suppresses natural testosterone and thus deprives the body of testosterone. Consumers should use testosterone in one form or another at a dose not lower than testosterone hormone replacement therapy (testosterone hormone replacement therapy).

Methandrostenolone has moderate estrogenic activity and is flavored by the enzyme aromatase, which is responsible for converting androgens to estrogen. Therefore, Dianabol is known for its estrogenic side effects such as fluid retention, risk of gynecomastia, high blood pressure (usually due to water retention) and possible increase in fat accumulation.

The drug is characterized by lower androgenic activity than testosterone, but the side effects and problems associated with it are still inherent in Dianabol, although not as pronounced as in testosterone. The risk score for androgenic side effects for methandrostenolone is 40-60, which is significantly lower than the corresponding testosterone score of 100, but the risk of adverse events still exists, especially in individuals with individual sensitivity. These phenomena include: increased risk of baldness in men in the presence of genetic predisposition, increased production of sebum (oily skin) and the appearance of acne, excessive facial and body hair.

Effect of Dianabol

Side effects of Dianabol

Dianabol (Methandrostenolone) – historical and general information about the drug.

The most significant side effect of Dianabol is that associated with estrogen, although studies have shown that the effect of Dianabol on the enzyme aromatase is moderate.

Most often when using the drug may occur swelling and accumulation of fluid, which leads to an increase in blood pressure, gynecomastia (enlarged mammary glands) is slightly less common and may develop acne. These side effects can sometimes be mitigated with antiestrogens such as the aromatase inhibitors Exemestane (Aromasin) and Arimidex, and the antiestrogenic drugs (SERMs) tamoxifen and Clomid.

In addition to estrogenic side effects, Dianabol may have androgenic effects (although less pronounced than testosterone). There is a risk of acne, oily skin, baldness in men and benign prostatic hyperplasia.
The next significant side effect of Dianabol is associated with increased stress on the liver system. The duration of the course, exceeding 4-6 weeks, can have an extremely negative effect on the liver. You can reduce the damage by using supplements containing components with hepatoprotective properties, avoiding high doses and the use of other drugs that adversely affect the liver.

Finally, Dianabol has a pronounced inhibitory effect on HGGO (hypothalamic-pituitary-gonadal axis). Clinical studies have been performed to investigate the inhibitory effects of Dianabol on testosterone. According to their findings, a dose of only 15 mg per day for 8 weeks resulted in a 69% reduction in total plasma testosterone levels.

In addition to these side effects, taking Dianabol may cause side effects typical of anabolic steroids. These include adverse effects on cholesterol and cardiovascular levels, as well as HGGO (hypothalamic-pituitary-gonadal) malfunction.

Side effects of Dianabol

Features of the drug

Dianabol (Methandrostenolone) – historical and general information about the drug
Because Dianabol has ana very strong bolico, its use to build v on muscle mass is not done in as high doses as many other oral painkillers.

Painkillers Steroids Dosage of methandrostenolone should be approached with extreme caution, taking into account the risk of adverse effects on the liver, as the use of higher doses will increase the negative effects.

It is important to note that the difference between a novice, intermediate, or advanced athlete is not an increase in Dianabol dose. Many advanced bodybuilders get all the benefits they want from a low dose.
The dosage of Dianabol in women should not be discussed, as this variant of the anabolic steroid is not very widely used in female athletes due to its pronounced masculinizing effects.

Features of the drug